Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies

When, where, and how much? Expression of

When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons

✍ Gan, Li ;Kaczmarek, Leonard K. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 2 views

The Kv3.1 potassium channel gene is expressed in neurons that fire action potentials at high frequencies. Neurons that express this gene, such as auditory brain stem neurons, have high-threshold voltage-dependent potassium currents that activate and deactivate unusually rapidly, and whose characteri