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Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents

✍ Scribed by Hameed P, Shahul; Chinnapattu, Murugan; Shanbag, Gajanan; Manjrekar, Praveena; Koushik, Krishna; Raichurkar, Anandkumar; Patil, Vikas; Jatheendranath, Sandesh; Rudrapatna, Suresh S.; Barde, Shubhada P.; Rautela, Nikhil; Awasthy, Disha; Morayya, Sapna; Narayan, Chandan; Kavanagh, Stefan; Saralaya, Ramanatha; Bharath, Sowmya; Viswanath, Pavithra; Mukherjee, Kakoli; Bandodkar, Balachandra; Srivastava, Abhishek; Panduga, Vijender; Reddy, Jitender; Prabhakar, K. R.; Sinha, Achyut; Jiménez-Díaz, María Belén; Martínez, María Santos; Angulo-Barturen, Iñigo; Ferrer, Santiago; Sanz, Laura María; Gamo, Francisco Javier; Duffy, Sandra; Avery, Vicky M.; Magistrado, Pamela A.; Lukens, Amanda K.; Wirth, Dyann F.; Waterson, David; Balasubramanian, V.; Iyer, Pravin S.; Narayanan, Shridhar; Hosagrahara, Vinayak; Sambandamurthy, Vasan K.; Ramachandran, Sreekanth


Book ID
124079784
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
770 KB
Volume
57
Category
Article
ISSN
0022-2623

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A series of boron-containing benzoxaborole compounds was designed and synthesized for a structureactivity relationship investigation surrounding 7-(HOOCCH 2 CH 2 )-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1) with the goal of discovering a new antimalarial treatment. Compound 1 demonstrates the best