✦ LIBER ✦
Aminoacyl-tRNA synthetase mutants degrade protein at a normal rate
✍ Scribed by Jeffrey L. Clark; Julie Rabe; Stuart M. Arfin
- Book ID
- 102310303
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 218 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
✦ Synopsis
The stability of both rapidly and slowly degraded proteins in wild type CHO cells is similar to that in three ts aminoacyl-tRNA synthetase mutants a t both permissive and non-permissive temperatures, although the degree of tRNA charging in the synthetase mutants differs considerably with temperature. These results indicate that the altered rate of protein breakdown seen under a variety of physiological conditions in eukaryotic systems is not mediated by uncharged tRNA.