Amino-terminal deletion of heparin-binding epidermal growth factor-like growth factor4−127 stimulates cell proliferation but lacks insulin-like activity

Heparin-binding epidermal growth factor-

Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3′-kinase and mitogen-activated protein kinase

✍ Kunlin Jin; Xiao Ou Mao; Gabriel Del Rio Guerra; Lan Jin; David A. Greenberg 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 306 KB

Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) stimulates cell proliferation in the adult mammalian brain, but the mechanism involved is unknown. To address this issue we treated mouse brain cerebral cortical cultures enriched in neuronal precursors with full-length HB-EGF