✦ LIBER ✦
Amine–boranes: effective reducing agents for the deracemisation of dl-amino acids using l-amino acid oxidase from Proteus myxofaciens
✍ Scribed by François-René Alexandre; David P. Pantaleone; Paul P. Taylor; Ian G. Fotheringham; David J. Ager; Nicholas J. Turner
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 111 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The deracemisation of DL-a-amino acids using L-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of D-amino acids were obtained in yields of up to 90% and e.e. >99%.