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Amine hydrochlorides by reduction in the presence of chloroform

โœ Scribed by Secrist, John A.; Logue, Marshall W.


Book ID
120605333
Publisher
American Chemical Society
Year
1972
Tongue
English
Weight
296 KB
Volume
37
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES


Selective reduction of secondary amides
โœ Byung H. Lee; Michael F. Clothier ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 89 KB

Secondary amides activated with a Cbz group can be reduced to their corresponding hemiaminals using lithium borohydride. Hydrogenation then removes the Cbz and hydroxyl groups to produce the related amine. Tertiary amides are not affected.