Amination Reactions of Aryl Halides with Nitrogen-Containing Reagents Catalyzed by CuI in Ionic Liquid

✍ Scribed by Jin-Can YAN; Li ZHOU; Lei WANG

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 117 KB
• Volume: 26
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200890015

✦ Synopsis

Abstract

CuI‐catalyzed coupling reactions of aryl iodides and electron‐deficient aryl bromides with nitrogen‐containing reagents, such as imidazole, benzimidazole, aliphatic primary and secondary amines, aniline, primary and secondary amides, in ionic liquid were developed. The reaction conditions involved the use of [Bmim][BF~4~] as the solvent, potassium phosphate as the base, and CuI as the catalyst. The CuI and [Bmim][BF~4~] could be recovered and recycled for five consecutive trials without significant loss of their activity.