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Amidrazones as Precursors of Biologically Active Compounds – Synthesis of Diaminopyrazoles for Evaluation of Anticancer Activity

✍ Scribed by Maria Teresa Cocco; Cenzo Congiu; Valentina Lilliu; Valentina Onnis


Book ID
102750495
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
861 KB
Volume
339
Category
Article
ISSN
0365-6233

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Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-β-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest