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Amidines. 4. Synthesis of tricyclic guanidines related to 1,2,3,5-tetrahydroimidazo[2,1-b]quinazoline, a new antihypertensive agent

✍ Scribed by Jen, Timothy; Bender, Paul; Van Hoeven, Helen; Dienel, Barbara; Loev, Bernard


Book ID
120579002
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
641 KB
Volume
16
Category
Article
ISSN
0022-2623

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## Abstract A new synthesis of 6‐carbomethoxy‐1,2,3,5‐tetrahydroirnidazo[2,3‐__b__][1,3]benzodiazocines **13** by the intramolecular cycloaddition reaction of methyl 2‐(1‐aziridinylmethyl)‐3‐(2‐ureidophenyl)propenoates **10** under Appel's dehydration conditions is described. The latter were readil