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Amide Derivatives of [6-(5-Methyl-3-phenylpyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic Acids as Potential Analgesic and Antiinflammatory Compounds.

✍ Scribed by Erden Banoglu; Cagla Akoglu; Serdar Uenlue; Esra Kuepeli; Erdem Yesilada; M. Fethi Sahin


Publisher
John Wiley and Sons
Year
2004
Weight
127 KB
Volume
35
Category
Article
ISSN
0931-7597

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In this study, we have explored the prevention of gastric side effects such as gastric lesions and bleeding while maintaining the high analgesic and anti-inflammatory activities by the derivatization of the carboxylate moiety into amides in [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl