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Amelioration of established collagen induced arthritis by systemic IL-10 gene delivery

✍ Scribed by Fellowes, R; Etheridge, C J; Coade, S; Cooper, R G; Stewart, L; Miller, A D; Woo, P


Book ID
110038662
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
655 KB
Volume
7
Category
Article
ISSN
0969-7128

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## Abstract ## Objective The phosphatidylinositol 3‐kinase (PI 3‐kinase)/Akt pathway is known to be activated in rheumatoid arthritis (RA) synovial tissue, which impacts cell growth, proliferation, survival, and migration. Phosphatase and tensin homolog deleted from chromosome 10 (PTEN) functions