Amelioration of diabetes by imatinib mesylate (Gleevec(R)): role of -cell NF- B activation and anti-apoptotic preconditioning

Phosphatidylinositol 3-kinase signaling

Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFκB transcription factors

✍ Jolyon Terragni; Julie R Graham; Kenneth W Adams; Michael E Schaffer; John W Tul 📂 Article 📅 2008 🏛 BioMed Central 🌐 English ⚖ 541 KB

## Background Phosphatidylinositol (PI) 3-kinase is activated by a variety of growth factor receptors and the PI 3-kinase/Akt signaling pathway is a key regulator of cell proliferation and survival. The downstream targets of PI 3-kinase/Akt signaling include direct regulators of cell cycle progress