๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Amelioration of cytotoxic-induced emesis with high-dose metoclopramide, dexamethasone and lorazepam

โœ Scribed by Martin C. Palmer; Barry M. Colls

Publisher
Springer
Year
1987
Tongue
English
Weight
340 KB
Volume
19
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.

โœฆ Synopsis

A double-blind randomised controlled trial comparing the antiemetic effects of sublingual lorazepam combined with high-dose, short course metoclopramide (3 mg/kg) infused twice 3 h apart with or without i.v. dexamethasone is reported. Sixty patients receiving a total of 209 cycles of potentially severely emetic cytotoxic chemotherapy were randomised to receive one or other antiemetic regimen. In those receiving platinum-based chemotherapy the addition of dexamethasone was associated with an improvement in freedom from nausea (P less than 0.01) and freedom from vomiting (P less than 0.05). In the non-platinum-based chemotherapy group the addition of dexamethasone led to a reduction in the duration and severity of nausea, and duration of vomiting (P less than 0.05 in each case). Both antiemetic regimens were well tolerated with a low incidence of adverse effects and could be administered easily in an outpatient setting.

๐Ÿ“œ SIMILAR VOLUMES

Improved control of cisplatin-induced em
Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients
โœ Mark G. Kris; Richard J. Gralla; Leslie B. Tyson; Rebecca A. Clark; David P. Kel ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 820 KB

A series of consecutive trials were undertaken to determine whether higher doses of intravenous metoclopramide and combinations of metoclopramide, dexamethasone, and diphenhydramine would improve antiemetic control or decrease treatment-related side effects in patients receiving cisplatin at 120 mg/

A randomized, double-blind comparison of
A randomized, double-blind comparison of the antiemetic effect of metoclopramide and lorazepam with or without dexamethasone in patients receiving high-dose cisplatin
โœ Suzanne H. Stephens; V. Lee Silvey; Richard H. Wheeler ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 414 KB ๐Ÿ‘ 2 views

Thirty-seven patients with advanced incurable malignancies who were receiving their first course of cisplatin (2 90 mg/mz bolus), alone or in combination with other antineoplastic agents, were entered in this randomized, double-blind study to determine the antiemetic efficacy of the addition of high

Continuous infusion of high-dose metoclo
Continuous infusion of high-dose metoclopramide: comparison of pharmacokinetically adjusted and standard doses for the control of cisplatin-induced acute emesis
โœ J. M. Brechot; J. P. Dupeyron; C. Delattre; Cl. Chastang; J. P. Laaban; J. Roche ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 461 KB

Metoclopramide was administered by continuous infusion to two groups each of 14 patients on chemotherapy, randomized to receive either doses adjusted to individual pharmacokinetic parameters or doses adjusted as usual to body weight. The mean plasma concentration at the end of the infusion in the ad