Amaryllidaceae Alkaloids from Lycoris radiata

✍ Scribed by Tao Feng; Yuan-Yuan Wang; Jia Su; Yan Li; Xiang-Hai Cai; Xiao-Dong Luo

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: German
• Weight: 182 KB
• Volume: 94
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.201000176

✦ Synopsis

Abstract

A phytochemical investigation on bulbs of Lycoris radiata resulted in the isolation of three new Amaryllidaceae alkaloids, named 5,6‐dehydrodihydrolycorine (1), 6__β__‐acetoxycrinamine (2), and (+)‐8‐O‐acetylhomolycorine α‐N‐oxide (3), together with eleven known alkaloids, 4–14. The structures of the new alkaloids were established by means of spectroscopic methods, and the known compounds were identified by comparison of their data with those in the literature. Compound 2 showed cytotoxicity against HL‐60, A‐549, and MCF‐7 cells, with IC~50~ values of 8.1, 24.3, and 15.0 μM, respectively.