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Amantadine may reverse punding in Parkinson's disease—Observation in a patient

✍ Scribed by Kenichi Kashihara; Takaki Imamura

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
68 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

Punding, complex stereotyped behavior, sometimes occurs in patients with Parkinson's disease under dopaminergic replacement therapy. Reduction of dopaminergic drugs may reduce the problem but risks enhancing motor impairment. We report a patient with Parkinson's disease presenting disabling punding, which was reversed by amantadine without aggravating motor function. Amantadine may reduce punding by blocking NMDA receptors, in the same manner as in levodopa‐induced dyskinesias. © 2007 Movement Disorder Society

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