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AM1 calculations on a series of bicyclic azetidin-2-ones and bicyclic 1,3-diazetidin-2-ones: investigations towards putative β-lactamase inactivators

✍ Scribed by Ashwini Nangia


Book ID
113257286
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
463 KB
Volume
251
Category
Article
ISSN
0166-1280

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✍ J. Frau; J. Donoso; F. Muñoz; F. García Blanco 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 905 KB

Semiempirical AM1, MINDO/3, and MNDO methods have been used in the study of the alkaline hydrolysis of P-lactam antibiotics through a base-catalyzed, acyl-cleavage, bimolecular mechanism. In this work, the hydroxyl ion has been chosen as nucleophilic agent and the azetidin-2-one ring like a model of