Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid

Nitric oxide synthase is present in the

Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels

✍ Vittorio Calabrese; Giovanni Scapagnini; Agrippino Ravagna; Rita Bella; Roberta 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 196 KB 👁 2 views

Nitric oxide (NO) is hypothesized to play a role in the immunopathogenesis of multiple sclerosis (MS). Increased levels of NO metabolites have been found in patients with MS. Peroxynitrite, generated by the reaction of NO with superoxide at sites of inflammation, is a strong oxidant capable of damag