Alzheimer’s Disease — From Basic Research to Clinical Applications

✍ Scribed by Prof. Dr. H. Förstl (auth.), Prof. Dr. H.-J. Gertz, Prof. Dr. Th. Arendt (eds.)

• Publisher: Springer-Verlag Wien
• Year: 1998
• Tongue: English
• Leaves: 313
• Series: Journal of Neural Transmission. Supplementa 54
• Edition: 1
• Category: Library

✦ Synopsis

As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer’s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer’s disease.

✦ Table of Contents

Front Matter....Pages I-VIII
Alzheimer’s disease: the size of the problem, clinical manifestation and heterogeneity....Pages 1-8
Progression of Alzheimer’s disease: variability and consistency: ontogenic models, their applicability and relevance....Pages 9-20
Mild cognitive impairment — an early stage of Alzheimer’s disease?....Pages 21-29
The prognosis of mild cognitive impairment in the elderly....Pages 31-50
Prevalence of mild cognitive impairment in an elderly community sample....Pages 51-59
Increase of optical illusion in demented patients....Pages 61-67
Age and dementia effect on neuropsychological test performance in very old age — influence of risk factors for dementia....Pages 69-76
Neuropathology of Alzheimer’s disease: a critical update....Pages 77-95
Evolution of Alzheimer’s disease related cortical lesions....Pages 97-106
What are the relations between Lewy body disease and AD?....Pages 107-116
The influence of coincidental vascular pathology on symptomatology and course of Alzheimer’s disease....Pages 117-127
Corpus callosum in Alzheimer’s disease and vascular dementia — a quantitative magnetic resonance study....Pages 129-136
What do we learn from a few familial Alzheimer’s disease cases?....Pages 137-145
Aberrancies in signal transduction and cell cycle related events in Alzheimer’s disease....Pages 147-158
Mechanisms of cell death in Alzheimer disease — immunopathology....Pages 159-166
Pathological immuno-reactions of glial cells in Alzheimer’s disease and possible sites of interference....Pages 167-174
Therapeutic strategies based on immunological hypotheses of Alzheimer’s disease....Pages 175-186
Risk factors for Azheimer’s disease during aging. Impacts of glucose/energy metabolism....Pages 187-194
Aging, dementia and calcium metabolism....Pages 195-200
Changes of intracellular calcium regulation in Alzheimer’s disease and vascular dementia....Pages 201-210
Free radicals in Alzheimer’s dementia: currently available therapeutic strategies....Pages 211-219
Free radicals in Alzheimer’s disease....Pages 221-236
Simulation of cortical cholinergic deficits — a novel experimental approach to study pathogenetic aspects of Alzheimer’s disease....Pages 237-247
Neuronal anion exchange proteins in Alzheimer’s disease pathology....Pages 249-257
Lymphocytes as cell model to study apoptosis in Alzheimer’s disease: vulnerability to programmed cell death appears to be altered....Pages 259-267
Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer’s disease....Pages 269-278
Neurotrophin binding to the p75 neurotrophin receptor is necessary but not sufficient to mediate NGF-effects on APP secretion in PC-12 cells....Pages 279-285
Aromatic alcohols as neuroprotectants....Pages 287-294
The therapeutic potential of tacrine....Pages 295-299
Sustained efficacy and safety of idebenone in the treatment of Alzheimer’s disease: update on a 2-year double-blind multicentre study....Pages 301-310
Clinical experience with donepezil (Aricept™) in the UK....Pages 311-315

✦ Subjects

Psychiatry; Neurology; Pathology; Human Genetics