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Alzheimer’s Disease: A Physician’s Guide to Practical Management

✍ Scribed by John Hardy (auth.), Ralph W. Richter MD, FACP, Brigitte Zoeller Richter DiplPharm (eds.)


Publisher
Humana Press
Year
2004
Tongue
English
Leaves
453
Series
Current Clinical Neurology
Edition
1
Category
Library

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✦ Synopsis


Alzheimer's disease (AD) is not only affecting increasingly large numbers of elderly and even middle-aged people in a worldwide epidemic, but also appears to be under-diagnosed and under-treated. In Alzheimer's Disease: A Physician's Guide to Practical Management, clinicians, scientists, and opinion leaders from all over the world provide a concise practical guide to the evaluation, assessment, and treatment of individuals with probable AD, illuminating the basic biology underlying the disease and outlining the many emerging therapeutic as well as promising preventive directions. On the clinical side, the authors focus on such issues as early changes and preclinical conditions-including mild cognitive impairment and predementia AD-how the patient presents, the state-of-the-art therapy, and the recent neuropsychiatric aspects of AD. Late-life issues are discussed, as well as the treatment of frequent comorbidities and the often-neglected dental care. On the practical side, guidance is offered to medical providers and caregivers on the deep feelings of isolation, loneliness, and despair that the illness can create in caregivers, and on how to overcome the consequent breakdown in communication with the patient. The authors also provide a comprehensible account of our current understanding of AD, as well as intriguing future strategies for its prevention and treatment, including stem cell therapy.
Comprehensive and practical, Alzheimer's Disease: A Physician's Guide to Practical Management not only offers physicians, caregivers, and all interested lay people a readable future-oriented overview of the disease, but also bridges the gap between basic science and the everyday challenges of treating and managing AD patients.

✦ Table of Contents


Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Genetics of Alzheimer’s Disease and Related Disorders....Pages 3-20
Neuropathology of Alzheimer’s Disease....Pages 21-31
Oxidative Stress in the Development of Alzheimer’s Disease and Other Dementias....Pages 33-38
Metabolism and Alzheimer’s Disease....Pages 39-47
Front Matter....Pages 49-49
Alzheimer’s Disease....Pages 51-55
The Economic Burden of Alzheimer’s Disease and Dementia....Pages 57-63
Potential and Established Risk Factors for Alzheimer’s Disease....Pages 65-71
Front Matter....Pages 73-73
Medical Diagnosis and Workup of Alzheimer’s Disease....Pages 75-87
Neuroimaging Techniques....Pages 89-102
Biological Markers in Alzheimer’s Disease....Pages 103-108
The Neuropsychology of Alzheimer’s Disease....Pages 109-120
Vascular Cognitive Impairment in Clinical Practice....Pages 121-126
Lewy Body Disease....Pages 127-135
Frontotemporal Lobe Dementia....Pages 137-143
Front Matter....Pages 145-145
Mild Forgetfulness....Pages 147-151
Mild Cognitive Impairment....Pages 153-156
Diagnosis of Predementia AD in a Clinical Setting....Pages 157-164
Loss of Olfactory Function in Patients With Alzheimer’s Disease....Pages 165-173
Front Matter....Pages 175-175
Treatment of Alzheimer’s Disease....Pages 177-178
Donepezil in Treatment of AD....Pages 179-186
Front Matter....Pages 175-175
Rivastigmine for Treatment of AD....Pages 187-192
Galantamine in Treatment of AD....Pages 193-202
Memantine in Treatment of AD....Pages 203-209
Alternative Treatment Options....Pages 211-213
Front Matter....Pages 215-215
Pain and Palliative Care in Late-Stage Dementia Patients....Pages 217-223
Cardiological Issues in Late-Stage Alzheimer’s Disease....Pages 225-232
Front Matter....Pages 233-233
Neuroprotection and Neurodegenerative Disease....Pages 235-243
Neurotrophic Factors for Prevention of Alzheimer’s Disease....Pages 245-252
Statins in Prevention and Treatment of Alzheimer’s Disease....Pages 253-257
Potential Role of Androgens and Androgen Receptors in Alzheimer’s Disease....Pages 259-271
Role of Nutrition in Prevention or Delay of Alzheimer’s Disease....Pages 273-279
Impact of Physical Activity on Prevention of Alzheimer’s Disease....Pages 281-286
Front Matter....Pages 287-287
Stem Cell Therapy for Alzheimer’s Disease....Pages 289-300
Secretases as Potential Targets for Treatment of Alzheimer’s Disease....Pages 301-308
AMPA Potentiation as a Treatment Option for Alzheimer’s Disease....Pages 309-314
Glycosaminoglycans as Potential Future Treatment of Alzheimer’s Disease....Pages 315-328
Implications of Research for Management of AD....Pages 329-334
Front Matter....Pages 335-335
Rating Scales and Outcome Variables Used in Clinical Trials....Pages 337-349
Front Matter....Pages 351-351
Gender Differences in Behavior of AD Patients....Pages 353-361
Management of Emotional and Behavioral Symptoms in AD....Pages 363-369
Front Matter....Pages 351-351
Assessment and Treatment of Neuropsychiatric Symptoms in Alzheimer’s Disease....Pages 371-385
Neuropsychiatric Symptoms in African American Dementia Patients....Pages 387-393
Resource Utilization by African American Dementia Patients....Pages 395-397
Apathy in Alzheimer’s Disease....Pages 399-405
Are Alzheimer’s Patients Aware of Their Deficits?....Pages 407-411
Front Matter....Pages 413-413
Diagnostic Family Conference in AD....Pages 415-420
Care, Caregiver Issues, and Communication With the Demented Patient....Pages 421-426
Dental Care of AD Patients....Pages 427-439
Long-Term Medical Care Issues....Pages 441-448
Loneliness and Depression in Caregivers....Pages 449-453
Frequently Asked Questions About Alzheimer’s Disease....Pages 455-460
Back Matter....Pages 461-479

✦ Subjects


Neurology


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