Peripheral reduction of β-amyloid is suf
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J. Gregor Sutcliffe; Peter B. Hedlund; Elizabeth A. Thomas; Floyd E. Bloom; Bria
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Article
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2011
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John Wiley and Sons
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English
⚖ 276 KB
Three loci that modify β-amyloid (Aβ) accumulation and deposition in the brains of a mouse model of Alzheimer's disease have been previously described. One encompasses the Psen2 gene encoding presenilin 2, a component of the γ-secretase activity responsible for generating Aβ by proteolysis. We show