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Alzheimer disease: Peripheral clearance of amyloid-β does not reduce brain levels of this peptide


Book ID
120155649
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
48 KB
Volume
9
Category
Article
ISSN
1759-4758

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Three loci that modify β-amyloid (Aβ) accumulation and deposition in the brains of a mouse model of Alzheimer's disease have been previously described. One encompasses the Psen2 gene encoding presenilin 2, a component of the γ-secretase activity responsible for generating Aβ by proteolysis. We show