Alzheimer A4 peptide, gamma-trace, leukoencephalopathy, and hereditary cerebral hemorrhage with amyloidosis–dutch type
✍ Scribed by Joost Haan; Raymund A. C. Roos
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 132 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA‐D), is an autosomal dominant disorder caused by the Dutch mutation (E693Q) in the β‐amyloid precursor protein. This mutation produces an aberrant amyloid β (Aβ) species (AβE22Q) and causes severe meningocortical vascular
## Abstract The amyloid β‐protein is a 39‐42 amino acid peptide that is deposited in senile plaques and in cerebral vessel walls in individuals with Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage with amyloidosis–Dutch type (HCHW A‐D), and, to a much lesser extent, normal agin