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Alveolar soft-part sarcoma: Further evidence by FISH for the involvement of chromosome band 17q25

✍ Scribed by Pierre Heimann; Christine Devalck; Chantal Debusscher; Eric Sariban; Esther Vamos

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 379 KB
Volume: 23
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199810)23:2<194::aid-gcc14>3.0.co;2-o

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✦ Synopsis

A cytogenetic study of an alveolar soft-part sarcoma, a rare tumor of probably myogenic origin, demonstrated a t(X;17)(p11; q25) as the sole chromosomal abnormality. Dual-and triple-color fluorescence in situ hybridization, performed on metaphase and interphase cells, confirmed the translocation between chromosomes X and 17 and demonstrated that this translocation resulted in loss of 17q25. Involvement of 17q25 has been described in four previously published cases of alveolar soft-part sarcoma, but without further characterization. Compared to our karyotype, it seems that the derivative chromosome 17 observed in the reported cases could also be the result of a t(X;17) with possible loss of the 17q25 band. If so, a 17q25 deletion and/or chromosome rearrangement between Xp and 17q leading either to a gene fusion or gene disruption could play an important role in the pathogenesis of alveolar soft-part sarcoma.

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