Aluminum toxicity following intravesical alum irrigation for hemorrhagic cystitis
✍ Scribed by Kanwar, Vikramjit S.; Jenkins, Jesse J.; Mandrell, Belinda N.; Furman, Wayne L.
- Book ID
- 102647330
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 904 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Mental status changes in an immunosuppressed child can be due to a variety of causes; aluminum toxicity is rarely considered. We report a teenage girl with acute lymphoblastic leukemia who developed mental status changes, speech disturbance, coarse tremor, and abnormal EEG findings following intravesical 1% alum irrigation and administration of aluminum-containing ant-acids. Her serum aluminurn levels were mildly elevated (14-22 pg/L, normal MI pg/ L), and bone marrow biopsy specimens demonstrated aluminum deposition on special staining (Krueger's method). All abnormalities resolved after a nine-week course of intravenous deferoxamine.