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Aluminum inhibition of microglial function in vitro

✍ Scribed by Bei Ping He; Michael J. Strong

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
163 KB
Volume
15
Category
Article
ISSN
0896-548X

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✦ Synopsis

Abstract

We have previously observed in vivo that chronic AlCl~3~ exposure in young adult New Zealand white rabbits induces a reversible motor neuron degeneration. In addition to the development of neurofilamentous aggregates within degenerating neurons, we have also observed a reduction of microglial number and activation. To determine if aluminum could directly effect microglial function in vivo, we used an immortalized murine microglial cell line (BV‐2) to study the effect of organic (aluminum lactate) and inorganic (AlCl~3~) compounds on microglial function. We have observed a dose‐dependent inhibition of phagocytosis, proliferation, migration, and release of TNF‐α and nitric oxide in the absence of inducing microglial death. Both organic and inorganic aluminum decreased the extent of LPS‐activated microglia‐mediated death of a motor neuron hybridoma cell line (NSC 34). These findings demonstrate that aluminum compounds can directly affect microglial in vitro. J. Trace Elem. Exp. Med. 15:141–152, 2002. © 2002 Wiley‐Liss, Inc.

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