Aluminum Chloride-Promoted Aminolysis of N-Tosyl Lactams
β Scribed by Bon, Eric; Biggs, Dennis C. H.; Bertrand, Guy; Bigg, Dennis C. H.
- Book ID
- 121245080
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 375 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Kinetics of the reaction of I-tosyl-3-methyl-imidazolium chloride with various amines were measured to examine the nature of sulfonyl transfer in enzymatic reactions. The activation parameters and the value of the Brdnsted exponent, B = 0.48, are consistent with a small degree of bonding between the
N-tosyl amides and lactams can be prepared easily and under mild conditions by the inter-or intramolecular condensation of carboxylic acids and secondary sulfonamides. The coupling reagent used is dicyclohaxylcarbodiimide (DCC) in the presence of 4-pyrrolidioopyridine (4-PPY) and the reactions proce