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Aluminum-27 nuclear magnetic resonance spectroscopy and imaging of the human gastric lumen

✍ Scribed by Armin Kaspar; Deniz Bilecen; Klaus Scheffler; Joachim Seelig

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
633 KB
Volume
36
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Aluminum NMR is proposed as a new imaging and spectroscopy modality. Its potential is exemplified by in vivo studies of the human stomach. The dissolution kinetics of aluminum‐containing drugs at physiological doses and their removal from the human stomach have been followed by ^27^Al magnetic resonance spectroscopy (MRS). Aluminum concentrations as low as 0.5 mg Al^3+^ in the human stomach can be detected. The time course of gastric emptying has been visualized with ^27^Al magnetic resonance imaging (MRI) under normal conditions and in the presence of an antimuscarinic agent, which reduces the gastric motor function. ^27^Al MRI is the only direct method to visualize the gastric pH. ^27^Al MRI opens new possibilities for medical and pharmaceutical science.

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