Alternatives to donor matching for control of graft-versus-host disease
β Scribed by Huib M. Vriesendorp; Wim M. Klapwijk; Trudi P. Visser; Chris Zurcher; Dirk W. Bekkum
- Publisher
- Springer-Verlag
- Year
- 1982
- Tongue
- English
- Weight
- 873 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0093-7711
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Graft-versus-host disease (GVHD) is an uncommon but potentially devastating complication following liver transplantation. Recently, it was shown that use of a human leukocyte antigen (HLA)-homozygous donor leading to one-way HLA matching significantly increases the risk of GVHD after living donor li
## Abstract Graftβversusβhost disease (GVHD) can occur following the transfer of allogeneic lymphocytes into immunosuppressed and, in rare cases, immunocompetent recipients. The initiation of GVHD requires the allorecognition of the recipient's disparate MHC molecules by the donor T lymphocytes (T