The industrial gas industry has experienced favourable safety performance in the storage and handling of cryogenic liquids. In recent years, however, there have been increasing challenges to further reduce the risk to employees, customers and the public from inadvertent spills and releases of LOX and LIN. With large flat-bottom storage tanks, serious spills or releases can result from external liquid piping damage or valve failure, tank overpressurization to the point of failure and overfill beyond the maximum safe liquid levels. This paper demonstrates by fault tree analysis the benefits of internal shut-off valves for spill prevention. It describes the risk reduction obtained by multiple pressure relief devices for prevention of overpressure failure of the tank. Overfill hazards are also described and quantified. With overthe-road LOX and LI N tanker loading, serious spills and releases can result from tanker pullaway during loading and from tanker overfill. Pull-away prevention/protection systems are discussed. A precision loading system to regulate the maximum load in tankers at or slightly below the road weight limit is described and its benefits as a hazardous overfill and spill protection system are quantified. Malfunction of cryogenic liquid vaporizer systems can lead to effluent temperatures that challenge the low temperature integrity of non-cryogenic downstream piping. The benefits of redundant low temperature monitors and flow shut-off systems as protection against piping failure and uncontrolled releases are demonstrated by fault tree analysis. While these systems focus on spill and release prevention or frequency reduction, the use of liquid retention systems such as curbs, gutters, sumps and dikes are briefly discussed, along with vapour barriers for vapour retention, as techniques for consequence reduction.