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Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype

✍ Scribed by Barathova, M; Takacova, M; Holotnakova, T; Gibadulinova, A; Ohradanova, A; Zatovicova, M; Hulikova, A; Kopacek, J; Parkkila, S; Supuran, C T

Book ID: 109999350
Publisher: Nature Publishing Group
Year: 2007
Tongue: English
Weight: 252 KB
Volume: 98
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6604111

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In the present study, we investigated the role of the extracellular signal-regulated protein kinase (ERK) in regulation of the hypoxia marker, carbonic anhydrase IX (CAIX). U0126, a specific inhibitor of MEK1/2, downregulated CAIX expression induced by true hypoxia and cell density. CA9 promoter act