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Alternative Splicing Regulation Impacts Heart Development

✍ Scribed by Thomas A. Cooper

Book ID
116352493
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
38 KB
Volume
120
Category
Article
ISSN
0092-8674

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## Abstract Cardiac troponin T (cTNT) exon 5 splicing is developmentally regulated such that it is included in embryonic but not adult heart. CUG‐BP and ETR‐3‐like factor (CELF) proteins promote exon inclusion, whereas polypyrimidine tract binding protein (PTB) and muscleblind‐like (MBNL) proteins