Objective. In previous studies, we suggested that cathepsin B, which is present at sites of cartilage remodeling in osteoarthritis (OA), may act as an antagonist of cartilage repair, an enhancer of the action of metalloproteinases, and a mediator of cartilage neovascularization and mineralization. A
✦ LIBER ✦
Alternative splicing of the 5′ region of cathepsin B pre-messenger RNA in rheumatoid synovial tissue
✍ Scribed by Raphaël Lemaire; René-Marc Flipo; Henri Migaud; Christian Fontaine; Guillemette Huet; Evelyne Dacquembronne; Robert Lafyatis
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 398 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0004-3591
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Objective. To compare the expression of cathepsin L, cathepsin D, and collagenase messenger RNA (mRNA) in synovial specimens from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Methods. The expression of cathepsins L and D as well as collagenase mRNA in synovial tissues from 8 pat