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Alternative splicing of fibronectin: Three variants, three functions

✍ Scribed by Jean E. Schwarzbauer

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 807 KB
Volume: 13
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950131006

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Fibronectin (FN) is a multi‐functional extracellular matrix protein required for cell adhesion and migration, blood clotting, wound healing, and oncogenic transformation. The functional complexity is paralleled by structural diversity in that multiple forms of FN are generated by cell type‐specific alternative splicing. In the rat, up to 12 different combinations of the three alternatively spliced segments (EIIIA, EIIIB, and the V region) are produced. What effects do these segments have on FN function? Recently, progress has been made in the identification of specific activities for the three Variants of the V region, V120, V95, and V0. FN‐mediated cell adhesion, FN synthesis and secretion, and incorporation into blood clots are differentially affected by these isoforms. These results suggest that cellular behavior is modulated by environmental cues provided by different types and proportions of alternatively spliced FN variants.

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