Alternative splicing and evolution: diversification, exon definition and function
โ Scribed by Keren, Hadas; Lev-Maor, Galit; Ast, Gil
- Book ID
- 109953187
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 452 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1471-0056
- DOI
- 10.1038/nrg2776
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Primary chicken mesenchymal cells from limb buds and vertebral chondrocytes have been used to study the changes that occur in alternative mRNA splicing of fibronectin exon EIIIA during chondrogenesis. The mesenchymal cell phenotype (exon EIIIA included) and chondrocyte phenotype (exon EIIIA excluded
The alternative exon EIIIA of the fibronectin gene is included in mRNAs produced in undifferentiated mesenchymal cells but excluded from differentiated chondrocytes. As members of the SR protein family of splicing factors have been demonstrated to be involved in the alternative splicing of other mRN