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Alternative processing for MHC class I presentation by immature and CpG-activated dendritic cells

✍ Scribed by Liying Chen; Mikael Jondal

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
248 KB
Volume
34
Category
Article
ISSN
0014-2980

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Proteolysis of the invariant chain (li) leads to the generation of abundant MHC class II-associated invariant chain peptides (CLIP), which bind in the MHC class II binding groove via supermotifs in a manner similar to that of antigenic peptides. We have engineered an li vector with the capacity to e