Alternative polymer supports for organic chemistry
โ Scribed by David E. Bergbreiter
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 263 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0198-6325
No coin nor oath required. For personal study only.
โฆ Synopsis
The use of polymers other than divinylbenzene crosslinked polystyrene as supports in organic chemistry is discussed. Insoluble polymer alternatives to DVB crosslinked polystyrene discussed include porous polyethylene supports, polymer-supported functional colloids, micron and submicron-sized particles and hollow spheres and one-dimensional supports. Soluble polymers including polyethylene, poly(alkene oxide)s, polyacrylamides, and fluorinated acrylates are discussed along with thermomorphic strategies where liquid-liquid separation of a biphasic systems is used as a way to effect polymer recovery in systems that are monophasic on heating.
๐ SIMILAR VOLUMES
The solid-phase synthesis of small organic molecules has received renewed attention since the first reports of the polymer-supported synthesis of compounds of therapeutic interest. Solid-phase synthesis is now a key component of the high-throughput synthesis and screening approach to drug discovery.