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Alternative PCR method for diagnosis of mutation causing activated protein C resistant Gln506-factor V

✍ Scribed by Judith S. Greengard; Xiao Xu; Sophie Gandrille; John H. Griffin


Book ID
116086959
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
385 KB
Volume
80
Category
Article
ISSN
0049-3848

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Detection of a common mutation in factor
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Hereditary predisposition to thrombosis due to activated protein C resistance (APCR) has been attributed to a missense mutation in the factor V gene at nucleotide 1691 (G to A), causing replacement of arginine at codon 506 with glutamine. Using an RFLP-PCR assay to detect this mutation, we measured