𝔖 Bobbio Scriptorium
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Alternative Models for Correlating Toxic Effects

✍ Scribed by J. S. Verducci


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
989 KB
Volume
29
Category
Article
ISSN
0323-3847

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✦ Synopsis


Two very different types of correlation ore examined. First, the problem of correlating two different toxic potentials, such as mutageneais and carcinogenesie, over a class of chemicals is discussed and shown to be quite difficult unleas strong assumptions are made about the dose-response curves for each effect. The second type of correlation is that of joint occurrences of symptoms over a population of 8ubjecta.A latent class model whose parametem are h e i r functions of dosage is proposed based on a two-stage theory of carcinogeneais. This model S U ~~I M E E E various alternative models in predicting multiple site tumors resulting from exposure to the solvent l,%-bntadiene.


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