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Alternative Lengthening of Telomeres Predicts Site of Origin in Neuroendocrine Tumor Liver Metastases

✍ Scribed by Dogeas, Epameinondas; Karagkounis, Georgios; Heaphy, Christopher M.; Hirose, Kenzo; Pawlik, Timothy M.; Wolfgang, Christopher L.; Meeker, Alan; Hruban, Ralph H.; Cameron, John L.; Choti, Michael A.

Book ID
123167346
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
284 KB
Volume
218
Category
Article
ISSN
1072-7515

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## Abstract Unlimited proliferative potential is a hallmark of cancer, and can be achieved through the activation of telomere maintenance mechanisms (TMMs). Most tumors activate telomerase, but a significant minority, mainly of mesenchymal origin, uses a recombination‐based, alternative lengthening