Mutations in alternative pathway complem
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Tara K. Maga; Carla J. Nishimura; Amy E. Weaver; Kathy L. Frees; Richard J.H. Sm
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Article
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2010
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John Wiley and Sons
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English
β 199 KB
Atypical hemolytic uremic syndrome (aHUS) is characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia, and occurs with an estimated incidence in the USA of 2 per 1,000,000. Disease pathogenesis is related to dysregulation of the alternative pathway (AP) of the com