𝔖 Bobbio Scriptorium
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Alternative approaches can greatly reduce the number of fish used for acute toxicity testing

✍ Scribed by Conny C. Hoekzema; Albertinka J. Murk; Beppy J. van de Waart; Jan C. M. van der Hoeven; Daphne F. de Roode


Book ID
111848136
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
56 KB
Volume
25
Category
Article
ISSN
0730-7268

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A new approach to minimizing the number
✍ E. SchΓΌtz; H. Fuchs πŸ“‚ Article πŸ“… 1982 πŸ› Springer-Verlag 🌐 English βš– 788 KB

170 acute toxicity determinations, carried out in rats, mice, and guinea pigs after oral and parenteral administration during the past 5 years, using 5 c~/5 9 animals per dose, were evaluated with respect to the possibility of a reduction of animals necessary for obtaining LDs0 values with limits of