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Alternative and Straightforward Synthesis of Dopaminergic 5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

✍ Scribed by Öztaşkın, Necla; Göksu, Süleyman; Seçen, Hasan

Book ID
120066785
Publisher
Taylor and Francis Group
Year
2011
Tongue
English
Weight
226 KB
Volume
41
Category
Article
ISSN
0039-7911

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An Alternative Synthesis of the Dopaminergic Drug 2-Amino-1,2,3,4-tetrahydronaphthalene-5,6-diol (5,6-ADTN)
✍ Süleyman Göksu; Hasan Seçen; Yaşar Sütbeyaz 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 67 KB

## Abstract Racemic 2‐amino‐1,2,3,4‐tetrahydronaphthalene‐5,6‐diol (5,6‐ADTN; **4**) was synthesized from 5,6‐dimethoxynaphthalene‐2‐carboxylic acid (**14**) in four steps (60% overall yield; __Scheme__). The crucial steps of the synthesis are __Birch__ reduction of **14** to the valuable synthon *