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Alternate Synthesis of Apixaban (BMS-562247), an Inhibitor of Blood Coagulation Factor Xa

✍ Scribed by Jiang, Jian'an; Ji, Yafei


Book ID
119967048
Publisher
Taylor and Francis Group
Year
2013
Tongue
English
Weight
381 KB
Volume
43
Category
Article
ISSN
0039-7911

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## Abstract Apixaban is a potent inhibitor of blood coagulation Factor Xa in the late stages of development. [^14^C]apixaban was synthesized with the 14C label in the two different lactam ring systems within the molecule for various __in vitro__ and __in vivo__ metabolism studies. A nine‐step synth