Alternate-day prednisone is more effective than intermittent prednisone in frequently relapsing nephrotic syndrome
✍ Scribed by J. Brodehl
- Book ID
- 104775606
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 837 KB
- Volume
- 135
- Category
- Article
- ISSN
- 0340-6997
No coin nor oath required. For personal study only.
✦ Synopsis
In a multicenter cooperative study the effectiveness and side-effects of two most widely used regimens for prolonged interrupted prednisone treatment were compared in children with frequently relapsing nephrotic syndrome: i.e., alternate-day prednisone vs. intermittent prednisone. Sixty-four children were admitted to the study, 30 of whom were allocated to an alternate-day, 34 to an intermittent group. Sixteen patients did not complete the full trial, which left 48 children for final evaluation (23 alternate-day, 25 intermittent). The protocol consisted of two 6-month periods. During the first 6 months patients received maintenance prednisone (alternate-day = 35 mg/m2/ 48 h, intermittent = 40 mg/m 2 on 3 out of 7 days). During the second 6-month period no maintenance * Supported by grants of VW Foundation *