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Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

✍ Scribed by Nobuto Kakuda; Mikio Shoji; Hiroyuki Arai; Katsutoshi Furukawa; Takeshi Ikeuchi; Kohei Akazawa; Mako Takami; Hiroyuki Hatsuta; Shigeo Murayama; Yasuhiro Hashimoto; Masakazu Miyajima; Hajime Arai; Yu Nagashima; Haruyasu Yamaguchi; Ryozo Kuwano; Kazuhiro Nagaike; Yasuo Ihara; the Japanese Alzheimer's Disease Neuroimaging Initiative

Book ID
112083542
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
203 KB
Volume
4
Category
Article
ISSN
1757-4676

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✍ Saori Hata; Sayaka Fujishige; Yoichi Araki; Miyako Taniguchi; Katsuya Urakami; E 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 331 KB 👁 1 views

Objective: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by c-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase in t