Altered Zn status by α-hederin in the pregnant rat and its relationship to adverse developmental outcome

Repeated administration of α-hederin res

Repeated administration of α-hederin results in alterations in maternal zinc status and adverse developmental outcome in the rat

✍ Duffy, Jodie Y.; Baines, Donald; Overmann, Gary J.; Keen, Carl L.; Daston, Georg 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB

The administration of alpha-hederin, an inducer of metallothionein, results in a secondary zinc deficiency that may be an important maternally mediated mechanism of developmental toxicity. Previous studies have shown adverse developmental outcome with a single administration of alpha-hederin to rats