Altered tissue content of trace metals in diabetic hyperinsulinaemic sand rats (psammomys obesus)
✍ Scribed by I. Raz; J. H. Adler; E. Havivi
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 430 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0012-186X
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✦ Synopsis
The concentrations of zinc, copper, and chromium in liver, kidney, muscle, bone and serum from control normoinsulinaemic and hyperinsulinaemic sand rats (Psammomys obesus) and from untreated spontaneously hyperinsulinaemic-hyperglycaemic sand rats were compared. A chronic hyperinsulinaemic-hyperglycaemic state was associated with a significant reduction (p less than 0.01) of zinc concentration in the liver, kidney and muscle but an elevation of zinc content in bone and of chromium in the liver. A hyperinsulinaemic-nor-moglycaemic state was not associated with similar changes in zinc concentration in the liver, kidney, muscle and bone. We conclude that in hyperinsulinaemic-hyperglycaemic sand rats there is a tendency to zinc depletion in several tissues. This depletion is not solely the result of a hyperinsulinaemic state but may be related to accompanying hyperglycaemia.