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Altered thiol and calcium homeostasis in oxidative hepatocellular injury

✍ Scribed by Giorgio Bellomo; Professor Sten Orrenius

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
672 KB
Volume
5
Category
Article
ISSN
0270-9139

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✦ Synopsis

Perturbation of cellular thiol homeostasis occurs during the early phase of oxidative cell injury in isolated hepatocytes. This perturbation, involves depletion of soluble and protein-bound thiols, and is associated with altered intracellular calcium (Ca") homeostasis resulting from inhibition of major Ca2+ transport systems. The result is sustained increase in cytosolic Ca2+ concentration which appears to trigger cytotoxicity.

The step-wise reduction of molecular oxygen to water results in formation of several, potentially toxic, intermediates, including superoxide anion-free radical, hydrogen peroxide and the hydroxyl radical:

O2 + ee 0; 0; + e-+ 2H' + H202 H202 + e-+ H' e OH. + H20 OH. + e-+ H' + H20

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