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Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder

✍ Scribed by Liang Wang; Chaozhe Zhu; Yong He; Yufeng Zang; QingJiu Cao; Han Zhang; Qiuhai Zhong; Yufeng Wang

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
466 KB
Volume
30
Category
Article
ISSN
1065-9471

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

In this study, we investigated the changes in topological architectures of brain functional networks in attention‐deficit/hyperactivity disorder (ADHD). Functional magnetic resonance images (fMRI) were obtained from 19 children with ADHD and 20 healthy controls during resting state. Brain functional networks were constructed by thresholding the correlation matrix between 90 cortical and subcortical regions and further analyzed by applying graph theoretical approaches. Experimental results showed that, although brain networks of both groups exhibited economical small‐world topology, altered functional networks were demonstrated in the brain of ADHD when compared with the normal controls. In particular, increased local efficiencies combined with a decreasing tendency in global efficiencies found in ADHD suggested a disorder‐related shift of the topology toward regular networks. Additionally, significant alterations in nodal efficiency were also found in ADHD, involving prefrontal, temporal, and occipital cortex regions, which were compatible with previous ADHD studies. The present study provided the first evidence for brain dysfunction in ADHD from the viewpoint of global organization of brain functional networks by using resting‐state fMRI. Hum Brain Mapp, 2009. © 2008 Wiley‐Liss, Inc.

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