Altered expression of mdm-2 and its asso
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Athanassios Dellas; Elisabeth Schultheiss; Alfonso C. Almendral; Fred Gudat; Mar
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Article
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1997
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John Wiley and Sons
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French
โ 109 KB
๐ 2 views
Recent results suggest that p53 inactivation is required for cervical-carcinoma development. The mdm-2 oncogene, which forms an auto-regulatory feedback loop with the normal p53 protein, has been found amplified in human carcinomas, thus abolishing the anti-proliferative function of p53. To investig