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Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer

✍ Scribed by Kuhmann, C.; Li, C.; Kloor, M.; Salou, M.; Weigel, C.; Schmidt, C. R.; Ng, L. W. C.; Tsui, W. W. Y.; Leung, S. Y.; Yuen, S. T.; Becker, N.; Weichenhan, D.; Plass, C.; Schmezer, P.; Chan, T. L.; Popanda, O.

Book ID: 126713675
Publisher: Oxford University Press
Year: 2013
Tongue: English
Weight: 653 KB
Volume: 23
Category: Article
ISSN: 0964-6906
DOI: 10.1093/hmg/ddt599

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## Abstract When DNA damage is induced by unprogrammed extrinsic events, activating‐cell‐cycle checkpoints delay cell‐cycle progression in the G1 or G2 phases and allow repair of a damaged template. In this study, we evaluated changes in gene expression upon radiation‐induced G2 cell‐cycle arrest u